Correlative microscopy is not a single technique but a varied collection of techniques that share a common approach. By applying several different microscopy techniques, such as light microscopy and electron microscopy, to a single sample, scientists can study it at a much broader range of magnifications than possible with a single technique. Not only does this allow them to conduct an initial low-magnification inspection of a sample to identify specific regions of interest for closer study, but it also generates a much greater range of information about those samples at various different scales.
This Essential Knowledge Briefing aims to provide a simple introduction to correlative microscopy. It describes the different microscopy techniques that are commonly combined together, outlines the benefits and challenges of these different combinations, and explores how correlative microscopy will develop and advance in the future.